Products
High-Purity Silybin (Silibinin) Powder Isolate 95% 98% | Standardized Milk Thistle Seed Extract
Technical Specifications
Comprehensive Quality Control Parameters
| Product Name | Silybin (Silibinin) |
| Botanical Source | Silybum marianum (L.) Gaertn. |
| Part Used | Seed |
| Specification | HPLC 95% / HPLC 98% |
| Appearance | Light yellow to white powder |
| Character | Odorless, slightly bitter taste |
| Solubility | Soluble in Acetone, Ethyl Acetate, Methanol, Ethanol; Sparingly soluble in Chloroform; Practically insoluble in Water. |
| Shelf Life | 24 Months (Properly Stored) |
| Storage Conditions | Store in a cool, dry, and dark place. Keep container tightly closed when not in use. |
Quality Distinction
The Standard of High-Purity Silybin
Silybin Isolate (95%/98%)
- ✔
Visual Grade: Crystalline white to off-white powder, indicating meticulous purification. - ✔
Solvent Profile: Processed exclusively with food-grade Ethanol; compliant with USP/EP standards. - ✔
Application Specificity: Pure flavonolignan monomer ideal for pharmaceutical R&D and targeted formulations.
Standard Extract
- ✘
Appearance: Brownish-yellow powder containing non-active plant lipids and pigments. - ✘
Solvent Methods: Potential use of various industrial solvents to maintain lower cost structures. - ✘
Composition: A complex mixture of isomers with lower concentration of the primary bioactive.
Technical Note: As the primary bioactive flavonolignan derived from Silybum marianum, Silybin is the most clinically researched isomer within the Silymarin complex. Our 98% grade offers the maximum concentration of this bioactive monomer, specifically refined to support antioxidant defense in hepatic cells and ensure superior batch-to-batch consistency.
Manufacturing Process
Traceable, All-Ethanol Purification Pathway
Seed Selection
Premium seeds, Identity testing, High flavonolignans.
Solvent Extraction
100% Food-grade Ethanol, No methanol/acetone.
Isolation
Enriched silymarin, Inert material removed.
Precision Purification
Chromatography + Recrystallization, Separates Isomers.
Crystalline Isolate
HPLC ≥95%/98%, White powder, Customized mesh.
Certificate of Analysis (COA)
| Product Name | Silybin (Silibinin) | Quantity | 500 kg |
| Batch No. | DMTL260328 | Test Date | 2026-03-29 |
| Manufacturing Date | 2026-03-28 | Expiry Date | 2028-03-27 |
| Items | Specification | Methods | Results |
| Color | White | GB1886.244-2016 | Conformity |
| Form | Powder / Granular | GB1886.244-2016 | Conformity |
| Assay | ≥98% | GB1886.244-2016 | 98.62% |
| Loss on Drying | ≤5.0 (g/100g) | GB1886.244-2016 | 1.94 |
| Ash content | ≤4.0 (%) | GB1886.244-2016 | 0.10 |
| Arsenic (as As) | ≤2.0 (mg/kg) | GB1886.244-2016 | Conformity |
| Lead (as Pb) | ≤5.0 (mg/kg) | GB1886.244-2016 | Conformity |
| Shelf Life | 24 months under standard storage, no antioxidant used. | ||
| Package | 25 kg/carton outside and double food plastic bags inside. | ||
| Storage | Store in a cool, dry place away from Moisture, Light, and Oxygen. | ||
Biological Functions
Core Mechanisms of High-Purity Silybin
01.
Liver Cell Protection
Stabilizes hepatocyte membranes and inhibits lipid peroxidation.
02.
Potent Antioxidant
Directly scavenges free radicals; significantly stronger than standard silymarin extract.
03.
Anti-inflammatory
Suppresses NF-κB pathway and reduces pro-inflammatory cytokines.
04.
Anti-fibrotic
Inhibits hepatic stellate cell activation, supporting liver tissue integrity.
05.
Bile Flow Support
Promotes bile secretion for healthy liver-gallbladder function.
Industrial Applications
Precision Solutions for High-End Markets
Liver Support Supplements
95%/98% silybin for high-dose, precision-label capsule and tablet formulations.
Pharmaceutical Intermediate
API-grade material specifically refined for professional liver-protective drug development.
Combination Formulas
Perfectly pairs with NAC, Phosphatidylcholine, or Vitamin E for premium multi-ingredient products.
Veterinary Liver Health
Targeting EU and North American companion animal markets for premium liver support.
Cosmetics & Topical
INCI compliant antioxidant active designed for premium anti-aging skincare.
Frequently Asked Questions
Quick Technical Answers for Professionals
Q1:
How is your 95%/98% Silybin different from standard 80% Silymarin?
Standard silymarin contains only ~30% silybin — the rest is a mixture of inactive or lower-activity flavonolignans (isosilybin, silychristin, silydianin). Our isolate delivers silybin as the dominant active ingredient at ≥95%/98%, enabling precise dosing, stronger antioxidant activity per gram, and clean label claims for your finished product.
Q2:
What extraction solvent do you use, and are there residual solvent concerns?
We use 100% food-grade ethanol throughout the entire process — no methanol, no acetone, no ethyl acetate. Residual solvent levels in the final product comply with ICH Q3C Class 3 limits, and a GC headspace test result is included in every batch Certificate of Analysis (CoA).
Q3:
Is this material suitable for phytosome manufacturing?
Yes. High-purity free silybin is the standard upstream raw material for silybin-phosphatidylcholine complex (phytosome) synthesis — the form with significantly enhanced oral bioavailability. We can also supply documentation supporting downstream phosphatidylcholine complex formulation if needed.
