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High Absorption Liposomal Resveratrol Powder 50% 70% Trans-Resveratrol Liposome Bulk Supply

Short Description:

Liposomal Resveratrol Powder is an advanced delivery system that encapsulates high-purity Trans-Resveratrol (CAS 501-36-0) within a stable phospholipid bilayer structure, directly overcoming the three critical formulation deficiencies of conventional resveratrol: near-zero aqueous solubility, rapid first-pass hepatic metabolism, and extreme sensitivity to light and oxidation. Available at 50% and 70% active loading grades, this ingredient enables water-dispersible, high-bioavailability formulations for premium longevity and wellness applications.


Product Detail

Product Tags

High-Performance Phyto-Delivery

LIPOSOMAL

RESVERATROL POWDER (50% / 70%)

Liposomal Resveratrol Powder is an advanced delivery system that encapsulates high-purity Trans-Resveratrol (CAS 501-36-0) within a stable phospholipid bilayer structure, directly overcoming the three critical formulation deficiencies of conventional resveratrol: near-zero aqueous solubility, rapid first-pass hepatic metabolism, and extreme sensitivity to light and oxidation. Available at 50% and 70% active loading grades, this ingredient enables water-dispersible, high-bioavailability formulations for premium longevity and wellness applications.

CAS 501-36-0
Lymphatic Uptake
Up to 70% Loading
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TECHNICAL SPECIFICATIONS

Product Name
Active Ingredient
Trans-Resveratrol (CAS 501-36-0)
Active Loading Capacity
50% / 70%
Encapsulation Efficiency (EE%)
≥ 90% (Typical)
Particle Size (Typical Range)
100nm – 300nm (Rehydrated)
PDI (Polydispersity Index)
≤ 0.3
Appearance
Fine Off-White to Light Beige Powder
Solubility
Dispersible in water (forms stable liposomal suspension)
Loss on Drying
≤ 5.0%
Heavy Metals (as Pb)
≤ 10 ppm
Storage Condition
Cool, dry, dark environment; sealed container
Shelf Life
24 Months

LIPOSOMAL DELIVERY PRINCIPLE

Standard Trans-Resveratrol, even at 98% purity, faces a fundamental pharmacokinetic paradox: it reaches the intestine largely intact but is almost immediately metabolized upon absorption, resulting in low and inconsistent plasma concentrations. Our liposomal manufacturing process resolves this through biomimetic phospholipid bilayer encapsulation.

The production process integrates hydrophobic resveratrol molecules into the internal lipid core of phospholipid vesicles through a controlled emulsification and spray-drying sequence. The resulting liposome structure mimics natural lipid transport vehicles found in the body. This structural similarity enables two key delivery advantages: Lymphatic Uptake Pathway — the phospholipid shell allows encapsulated resveratrol to be absorbed primarily via the intestinal lymphatic system, partially bypassing hepatic first-pass metabolism; and Physical Stability Shield — the bilayer acts as a physical barrier against oxygen, UV light, and aqueous degradation. The final spray-dried powder retains water-dispersible properties while offering the handling convenience of a conventional dry ingredient.

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KEY ADVANTAGES

Dual-Grade Flexibility (50% & 70%)

Two distinct loading grades allow formulators to calibrate cost-per-active and target dosage weight for different product tiers.

Superior Water Dispersibility

Disperses readily into aqueous systems, unlocking functional beverages, stick packs, and effervescent formats previously inaccessible with standard resveratrol.

Light and Oxidation Protection

The phospholipid bilayer acts as a molecular shield against discoloration and potency loss during manufacturing and storage.

Optimized Lymphatic Absorption

Aligns with the body’s natural fat-absorption pathway, providing more consistent systemic exposure compared to unencapsulated crystalline resveratrol.

EVIDENCE & LAB VERIFICATION

1. HPLC Active Assay

Every production batch undergoes HPLC analysis to confirm declared Trans-Resveratrol loading (50% or 70%).

2. DLS Particle Size Analysis

Dynamic light scattering analysis verifies stable liposome formation within the 100nm–300nm range upon rehydration.

3. Encapsulation Efficiency (EE%) Reporting

Batch-typical EE% values (≥ 90%) are reported to confirm genuine encapsulation within the liposome structure.

4. Heavy Metal Screening

Rigorously monitored to comply with global safety standards (Pb ≤ 10 ppm, As ≤ 1 ppm, Cd ≤ 1 ppm, Hg ≤ 0.1 ppm).

Functional Roles of Liposomal Resveratrol

FUNCTIONAL ROLES

1. Endogenous Antioxidant Defense Support

Trans-Resveratrol functions as a potent polyphenol that supports the body’s own antioxidant signaling pathways, contributing to the reduction of oxidative stress in cellular environments.

2. Cardiovascular Wellness Support

Supports healthy vascular tone and circulatory function through its interaction with endothelial cell pathways, making it a key active in premium heart-health formulations.

3. Cellular Longevity Pathway Support

Resveratrol is widely recognized as a sirtuin-activating compound (STAC). Our liposomal form enhances its suitability for “longevity stack” formulations targeting cellular aging mechanisms.

4. Metabolic Balance Support

Contributes to the maintenance of healthy glucose metabolism and insulin sensitivity pathways, relevant for metabolic wellness product categories.

INDUSTRIAL APPLICATIONS

Skincare
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1. Premium Longevity & Anti-Aging Capsules

Primary application for the 70% grade, where maximum active density within a small capsule footprint is essential.

2. Functional Beverage Mixes & Stick Packs

Water-dispersible liposomal powder uniquely suited for resveratrol-fortified sachets, functional waters, and effervescent tablets.

3. Multi-Ingredient Wellness Powders

Ideal for premium meal replacement shakes, greens blends, and “beauty-from-within” powder formulations.

4. Soft Gel & Liquid Capsule Filling

Can be reconstituted into a stable suspension for liquid-fill softgel applications.

OEM & PACKING

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OEM

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CERTIFICATES

Transport CRS

TRANSPORTATION

Packaging CRS

PACKAGING

TECHNICAL FAQ

Q1: Why is liposomal resveratrol more valuable than standard 98% Trans-Resveratrol powder for finished product formulation?
A: Standard 98% resveratrol, despite high purity, is rapidly degraded by hepatic first-pass metabolism before reaching systemic circulation and is practically insoluble in water — severely limiting dosage formats. Liposomal encapsulation addresses both issues simultaneously: the phospholipid shell facilitates absorption via the lymphatic pathway (partially bypassing first-pass metabolism) and converts the insoluble crystal into a water-dispersible delivery vehicle.
Q2: Does the high 70% active loading compromise the liposome’s dispersion speed or structural stability?
A: No — dispersion behavior depends on phospholipid shell integrity, not active loading density. In a well-formed liposome, resveratrol is distributed within the lipid core as a stable matrix. Upon water contact, the outer phospholipid layer hydrates and disperses normally. Both the 50% and 70% grades pass the same DLS and EE% verification.
Q3: How should liposomal resveratrol powder be handled during capsule or tablet manufacturing to preserve its encapsulation structure?
A: Blend at room temperature and avoid prolonged high-shear mixing, which can rupture phospholipid vesicles. For tablet compression, keep compression forces within standard ranges and avoid high-heat processes. Standard capsule-filling conditions are fully compatible. Store bulk in sealed, nitrogen-flushed containers away from light and heat.


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